Compared with kidneys from the sham group, the kidneys in the I/R, intralipid and 1 ml/kg EIso groups showed significant renal damage demonstrated by severe tubular dilatation, tubular epithelial cell swelling, vacuolar degeneration and necrosis, many tubular epithelial cells sloughing from the basement membrane, tubular luminal obstruction, and interstitial hemorrhage and edema.
Moreover, high P&I mortality was not a sufficient condition to indicate severity, as demonstrated by the severe 2010 11 season.
This requirement has been previously demonstrated by the severe pulmonary granulomas and failure to eliminate the bacteria presented by athymic nude mice infected with R. equi [33].
The essential role of protein glycosylation for normal brain development has been demonstrated by the severe brain phenotypes in Walker-Warburg syndrome and Muscle-Eye-Brain disease.
Imprinted genes are important during human development, as demonstrated by the severe syndromes caused by a loss of imprinting (LOI), i.e, the expression of both parental alleles, or the complete loss of expression.
In addition to the similar expression pattern, the pattern of defects is also similar between B and T cell development in Egr-2 cTg mice, as demonstrated by a severe reduction of pro-B cells and enhanced terminal B cell maturation, suggesting a common mechanism operated by Egr-2 in both lineages.
The importance of peroxisome biogenesis for cell homeostasis is clearly demonstrated by the severe clinical phenotype of peroxisomal biogenesis disorders (PBDs).
The protective role of neutrophils is demonstrated by the severe and sometimes fatal infections that are developed by patients with congenital or induced neutrophil deficiencies; in these patients the risk of infection is proportional to the extent of neutropenia [ 2].
However, Tg alpha43 animals show a reduced tolerance to 14-day PE treatment, demonstrated by reduced survival and severe cardiac hypertrophy.
EHV-1 is a major pathogen which defies control measures as demonstrated by the increase in severe, and often fatal, disease outbreaks which occur despite vaccination [7].
After all, given the severe deficiencies demonstrated by all of the Australian batsmen, apart from Clarke and Smith, on raging turners, if the team are unlucky enough to be stuck with such a pitch, surely they will need a specialist spinner who can bowl the opposition out very cheaply?
