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CarD does not make significant interactions with σA but interacts with the promoter DNA from −14 to −10 from the opposite, (distorted) minor groove side of the DNA such that the σA/DNA interactions and the structure of the transcription bubble in RPo and CarD/RPo are essentially the same.
Although not all nine amino acids interact strongly with the MHC binding site, all of them contact and make significant interactions with the MHC molecules [57].
In the TTR∶OE1 structure, the halogenated phenyl ring moves away from the inner binding pocket and does not make significant interactions with the Ser117 and Ser117'.
This is perhaps not surprising as the sulphonamide group does not appear to make significant interactions with the protein.
As a group, K260, K263, K265, and K270 form a cluster and do not make significant interactions with the protein surface.
In the lead compound 9, the third —NHR phenol protrudes into the large CYP121 water‐filled active‐site cavity, but does not appear to make significant interactions directly with CYP121, and instead only forms hydrogen bonds to the interstitial water network.
Similar(54)
This is consistent with data on the orthologous protein from B. burgdorferi BB0405, which was shown to be monomeric while not making significant interactions with other major OM-proteins [ 65].
Inspection of the dimer interface reveals that three residues in this loop, Thr 123, Ala 125, and Asp 131, make significant intersubunit interactions.
Switch 2 predominantly contacts CR3 and portions of α6, both of which make significant DH-DH domain dimer interactions [7].
As a PI, I could make significant contributions to the scientific community while enjoying the interaction with students.
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