Sentence examples for make substantial interactions from inspiring English sources

Finally, and quite significantly, Ii1's hydroxamate moiety, amide backbone, and P2' residue all make substantial interactions not only with residues in the N-terminal portions of IDE involved in zinc-binding and catalysis, but also with multiple residues within distal C-terminal portions of the protease (Fig. 4B; Fig. S4).

The thioether moiety fits between Ile 109 and Gly 172, although the furan core does not make substantial interactions with MTIP.

Examination of the structure shows that N40, L41 and M42 make substantial interactions with the body of the serpin (Fig 1C).

A second, higher occupancy conformer is involved in contacts with symmetry-related molecules and calcium ions in the lattice but, nevertheless, makes substantial interactions with Arg48 from the β3 to β4 loop.

It makes substantial interactions with both tubules at their luminal joint, with an estimated total contact area between the stem and the A- and B-tubule of ∼5200 Å.

However, inclusion or exclusion of hypertension in the models did not make substantial differences in the observed associations except as noted in the interaction analyses.

Together we can make substantial strides forward.

"They need to make substantial claims".

Willing to make substantial improvements to webOS?

We did not make substantial alterations to the original data.

By dodging these costs, criminals can make substantial profits.