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In RND-dependent tripartite pumps, the MP domain is known to make extensive interactions with the periplasmic extension of IM transporters [5,41].

The side chains of conserved residues in the PxIxIT sequences make extensive interactions with conserved residues in Cn, while those of nonconserved residues are solvent exposed.

Overall these data show that CNCs have the capacity to make extensive interactions with loci on other chromosomes.

The hydrophobic side chains from residues M200, L201, F204, and M205 from helix α9 make extensive interactions with hydrophobic residues from residues L186, L187, F190 and I193 from helix α8 at the TMD-binding groove.

(D ) Y6 and Y8 make extensive interactions to µ1 residues.

Other regions of the aptamer make extensive interactions with the large lobe of the kinase domain, remodeling basic regions of the protein so that they can better interact with the polyanionic phosphodiester backbone of the RNA.

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Similar(51)

In the SaMCAT structure, the N-terminal expression peptide of a neighboring molecule running in the opposite direction of malonyl-CoA makes extensive interactions with the highly conserved "Gly-Gln-Gly-Ser-Gln" stretch, suggesting a new design platform.

Molecular modeling of these peptides into the binding site indicates that these complexes are fitting well into the site and making extensive interactions with the residues crucial for PfEMP-1 binding.

From the model of the assembled AcrAB/TolC pump [12] it is clear that the outer membrane channel makes extensive interactions with the α-helical subdomain of the MFP.

After a short coil, residues 34 43 (α0) form an α-helix that both caps the bottom of the barrel and makes extensive interactions with neighboring monomers (Figs. 2a, 2c, and 4).

Arg1410 makes several critical hydrogen bonds to phosphates, and the pantetheine arm makes extensive interactions with the substrate binding loop that closes off CoA binding in p300.

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