Sentence examples for major unsolved question from inspiring English sources

A major unsolved question when considering the autophagic functions of Bcl-2 and Bcl-xL was their respective localisation: Beclin 1 and hVPS34 are reported to localise at the trans-golgi network, while enforced ER-targeted Bcl-2 and Bcl-xL were reported to regulate autophagy [19], [24].

Specifically, involvement of Ca2+ in the rd1 pathology is a major unsolved question.

A major unsolved question is how the maternal alleles of genes that are demethylated before fertilization remain hypomethylated several days after fertilization, in the spite of the presence of small RNAs that normally target DNA methylation to these sequences.

It is still a major unsolved question whether paracetamol induces cell death of LSEC directly or whether the observed LSEC damage and the resulting hemorrhagic alterations are primarily a consequence of the release of cytotoxic compounds from dying hepatocytes.

A major unsolved question in speech perception for humans as well as other species regards the relative contribution that those different acoustic features have in the perception of speech sound contrasts.

One of the major unsolved questions in evolutionary biology is why the vast majority of species fails to adapt to conditions outside their present niche and, as a consequence, usually exhibit geographically confined range limits [ 1- 5].

The review concludes with a brief summary of major unsolved questions concerning this very small, yet potentially complex magnetosphere.

How eukaryotic genomes are packaged into compact cylindrical chromosomes in preparation for cell divisions has remained one of the major unsolved questions of cell biology.

But making them in quantity is a major unsolved challenge.

The FBI investigation remains in its early stages, but his motive is the principal unsolved question.

"There is an unsolved question underlying this," Stevenson says.