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Additionally, it is suggested here that even under the putative scenario of MF being the major selection pressure for mdr1 amplification, the presence of an ART partner drug is not antagonistic to this process.
The authors emphasize adaptation to hyperthermophily as the major selection pressure for the formation of the archaeal domain by thermoreduction.
This strategy would likely have a significant impact on resistance evolution because the major selection pressure would be removed.
Interestingly, persistence of negative feedback is found in tumour cells and seems to represent a major selection pressure for mutations in modulators of these feedback programmes (Chandarlapaty, 2012).
DOI: http://dx.doi.org/10.7554/eLife.05557.013 Because seed bank loading is a key component of fitness in ruderal plant populations (Grime, 1988), control of progeny behaviour likely generates a major selection pressure on flowering time control.
The differential ability of birds to preen or groom various parts of their bodies also exerts a major selection pressure on louse which may affect their diversity on a host.
Similar(52)
Three major selection pressures have been identified as follows: settling time, volume exchange ratio and discharge time.
This review demonstrates that these three major selection pressures can all be unified to one, the minimal settling velocity of bioparticles, that determines aerobic granulation in SBRs.
The experimental treatments mimicked the major selection pressures experienced by the snails in each habitat, crab predation and hydrodynamic forces due to wave action.
In particular, dietary adaptation through taste sensory mechanisms is emerging as a major evolutionary selection pressure [ 7, 8].
Our data are consistent with a model of enhanced viral entry efficiency combined with host milieu as major selective pressures driving episodic selection.
Related(20)
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