Sentence examples for considerable selection pressure from inspiring English sources
Furthermore, therapies produce a considerable selection pressure in epigenetic marks that can contribute to therapy resistance.
The widespread use of such programmes has substantially reduced clinical disease, especially that associated with large strongyle species; however, high treatment frequency has led to considerable selection pressure for anthelmintic resistance, particularly in cyathostomin species.
On the other hand, such dosage still exerts considerable selection pressure.
Because rhodopsin has very high expression levels in mammals [ 56], the gene should be experiencing considerable selection pressure to minimize translation errors while maintaining a high translation rate.
We demonstrate later that there is considerable selection pressure on the prey to time this turn so that it occurs close to the contact point (but not so close that the predator catches it).
Persistent infection of nonactivated T-lymphocytes (where low levels of viral replication occurs) has been detected in individuals on successful HAART with BDL. 5 Thus, it is apparent that HAART exerts considerable selection pressure on HIV, which provides partial restoration of the host immune system.
Thus, our study indicates the presence of a considerable positive selection pressure in diversification of the Prochlorococcus core genome, which in turn, suggests an appreciable role of random genetic drift in vertical niche partitioning of the strains.
2) The sample set is heterogeneous in terms of cancer of origin and derivation from primary cancers and cultures that are likely to have been subjected to considerable in vitro selection pressure and/or founder effects.
Higher duplicability may enforce the slower evolutionary rate on AD genes in contrast to other two classes since duplicated genes encounter more purifying selection than singletons even though shortly after the duplication, they experience a considerable relaxation of selection pressure [ 25].
Although we were unable to detect ex vivo CD8 T cell responses to this epitope in the Irish cohort, the highly significant HLA-A*03 'footprint' provides robust evidence that this epitope was likely to have been under considerable T cell-mediated selection pressure relatively early on in the course of infection.
When a gene is highly transcribed and regulated by a single promoter, the selection pressure prevents any considerable change in the promoter's structure to provide for its effective binding to the polymerase.
