Sentence examples for substantial selection pressure from inspiring English sources
Typically, a strong correlation between amino acid mutations is interpreted as evidence of functional interactions under substantial selection pressure.
Moore et al. [33] have suggested that the immune pressure from the cellular arm of the immune system in particular, CD8+ T cells interacting with MHC-I epitopes presented on the surface of infected cells can exert substantial selection pressure on HIV.
We demonstrated that substantial selection pressure is applied to CpG pairs in CGIs independently from CGI location in the reference to gene starts locations, which implies functional importance of CpG pairs.
Since resistance has most commonly occurred in most patients undergoing long-term linezolid therapy [ 2], and the heavy use of linezolid in the patients may create substantial selection pressure in favor of linezolid-resistant isolate [ 5].
However, in the ICU, a statistically significant increase in the use of linezolid was observed in 2004 and in 2007 (0.58 vs. 1.34 defined daily doses/100 patient-days, respectively); heavy use of linezolid may have created substantial selection pressure in favor of the linezolid-resistant isolates.
This can stem from a strong selection pressure of host in choosing its mycobionts as suggested from the substantial host phylogeny effect on ectomycorrhizal fungal richness and community.
This suggests that significant selection pressure exists to maintain them.
"There are such strong selection pressures for attractiveness," he said.
The substantial variety of selection pressure in microbials may be explained by factors such as particular living environments, frequent mutation, rapid generation, etc.
I hypothesize that if the virus encounters substantial population-specific selection pressures when entering a new population, a selection shift signature may be detectable on the branches of phylogenetic trees that separate subtypes.
Furthermore, there may be substantial differences in selection pressures on reciprocal amino acid substitutions [ 10]: changes from polar to non-polar amino acids in human proteins are more permissive than vice-versa.
