Sentence examples for major pathways have from inspiring English sources

Two major pathways have evolved to repair DNA DSBs in somatic mammalian cells and thereby suppress genomic instability: non-homologous end joining (NHEJ) and homologous recombination (HR) (for reviews see [40], [41]).

For caspase-dependent apoptosis two major pathways have been identified: the extrinsic pathway, which involves triggering of death receptors like tumor necrosis factor (TNF) receptor, FAS/CD95-APO-1 and TRAIL/APO-2, and the intrinsic pathway in which the mitochondrion is the central regulator [2].

In this way, two major pathways have been involved.

To properly heal the more problematic double-strand breaks (DSBs) two major pathways have developed.

For the development of colorectal cancer, two major pathways have been described.

In animal cells, thus far two major pathways have been identified in mitotic spindle assembly.

A model for at least two major pathways has emerged based on the existence of these two distinct groups of lesions [ 2, 3].

BMPs play an important role during all stages of embryonic development, and although only two major signaling pathways have been characterized (p38 and Smad pathways), the BMP signaling is complex and includes cross-talk with other major signaling pathways and negative feedback mechanisms [34], [48], [49].

Two major signaling pathways have been described for apoptosis induction.

Two major proapoptotic pathways have been described.

Two major triggering pathways have been defined for the caspase cascade.