Sentence examples for major drawback has from inspiring English sources

However, a major drawback has been that ray tracing requires access to the entire scene data base.

Up to now, this major drawback has drastically inhibited their possible applications in industrial or domestic fields.

One major drawback has been the attrition caused by the lack of a reliable biological indicator (biomarker) to predict toxicity and efficacy early in the development pipeline.

A major drawback has been the substantial difficulty in designing HIF-specific inhibitors owing to the intracellular nature of the protein complex and the lack of active sites to which small molecular inhibitors are usually designed (Scheuermann et al., 2013).

While the concept of surface displaying glycosylated eukaryotic proteins on prokaryotic bacteria using the above approach was proven successful, the major drawback has been the initial low expression of the target fusion protein produced by the transient CHO-S expression system.

Its major drawbacks have been the need for frequent monitoring and numerous interactions with other drugs and food [ 1].

However, it has a major drawback of having a low ionic conductivity (10-8 to 10-5 Scm-1) at room temperature [4].

Imposition of boundary conditions of the transformed equations is a major drawback that has to be tackled, especially for three-dimensional problems.

Despite the widespread use of cisplatin as an antitumour agent, its remarkable antitumour effects coincide with two major drawbacks that have markedly limited cisplatin-based chemotherapy.

It has one major drawback, however: the space has no plumbing or electricity or interior walls, and it needs work estimated to cost $2 million or more, depending on the detail, before anyone can move in.

The only major drawback so far has been a hairline crack that appeared in the case; Sony replaced it under warranty.