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Another major issue has been quality of teaching.
A major issue has been who would lead the government.
The Zika virus could be a factor in the low level of foreign purchases but a major issue has been domestic apathy.
One major issue has finally been resolved: according to court papers, Judge Allan L. Gropper in the United States Bankruptcy Court in Manhattan ordered late last month that the LeRoys' license be extended from Jan . 31to Feb. 14, long enough for the family to remove items it owns and to conduct the auction.
It's deja vu for progressives this week as the Obama administration's latest concession to Republicans on a major issue has gone, once again, unreciprocated.
Another major issue has been highlighted in relation to the application of antibiotic resistant probiotics, the antibiotic resistant gene can be transferred between organisms.
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One major issue had been the lack of guarantees that volunteers would be evacuated to Western hospitals if they fell ill.
One of the major issues has been safety.
"One of the major issues has involved Kirkgate market, the largest covered market in Europe.
It's a choice between a moderate and an erratic conservative, someone who on a lot of the major issues has been just wrong," Mr. Santorum said on the ABC News program "This Week".
If a general agreement on tradeoffs and concessions on the major issues hasn't been reached by then, there's no way a comprehensive package can be prepared that could clear Congress before the President's special authority runs out.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com