Sentence examples for major difficulty has from inspiring English sources

The major difficulty has been in establishing a balance between eliciting a strong immune response to the vectored antigen and reactogenicity.

A major difficulty has been to establish differences in the level and period of past exposure, a prerequisite for hypothesis testing.

One of the major difficulties has been to manipulate the proliferation of specific progenitor subtypes while preserving a correct cortical lamination and structure.

Major difficulties have arisen from the inherent mobilities of phosphorylated and glycosylated side chains.

Other major difficulties have emerged in Washington's negotiations with the government of Yemen, which has about 105 citizens at Guantánamo.

Two major difficulties have been hindering such integration efforts.

Two major difficulties have been identified as responsible for the low perception of M&E in general, and they are: feelings of being controlled and perception of M&E tasks as an additional burden.

The major difficulties have more to do with the fact that ecology is a relatively young science, and there is much that we don't yet understand about it, says Polasky, echoing colleagues.

Despite the success of existing algorithms, a major difficulty that has not been sufficiently addressed is that of predicting rare labels.

"The major difficulty comics have is their distribution, kids have other things to spend their time and money on these days like playing computer games and things like that, We do workshops and lots of kids want to create their own stories and do enjoy reading them, but there are definitely challenges".

In my view, the major difficulty we have today with Strindberg is his difficulty.