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On the one hand the Zhuocang Tibetans have an extremely open attitude towards different cultures, yet, on the other, they scrupulously adhere to their own core culture, maintaining a type of attitude that sets boundaries without closing doors.

Thus, we conclude that trx regulates neuroblast heterogeneity by maintaining a type II neuroblast functional identity.

These data strongly suggest that Trx regulates neuroblast heterogeneity by maintaining a type II neuroblast identity.

We assessed whether the histone methylation activity of Trx is required for maintaining a type II neuroblast functional identity.

Thus, we tested whether the core components of the SET1/MLL complex are required for maintaining a type II neuroblast identity.

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We can maintain a type of open mindedness that does not risk casting us into willful ignorance.

The expression patterns of these proteins are shown in Figure 5. Detection of EBNA-1, LMP-1 and EBNA-3 proteins clearly showed that the recombinant GFP-EBV was capable of transforming primary B-cells into LCLs and was also able to maintain a type III latency program.

These results indicate that Trx maintains a type II neuroblast functional identity by regulating the transcription of specific target genes.

10.7554/eLife.03502.010 Figure 4. Btd likely acts downstream of Trx to maintain a type II neuroblast functional identity.

btd mutant type II neuroblasts maintained a type II neuroblast marker expression profile in all stages examined, but these clones displayed a time-dependent reduction in INPs.

Furthermore, LL03 maintained a type II CRISPR element with the cas9 gene involved in target interference, whereas DS20 had type I CRISPR elements with the cas3 gene [ 17].

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