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The genetic diversity in the population is maintained by mutation.
Selection results from increased replication due to higher fitness, and coupling between haplotypes is maintained by mutation.
At this equilibrium, the trait variance is maintained by mutation, which increases variance, and by genetic drift and stabilizing selection, which decrease variance.
This may be considered as the background frequencies maintained by mutation bias, which leads to the expected NC/NU ratio of 0.8001 (=NC+G/NA+U) and that of NA/NG ratio of 1.2490 (=NA+U/NC+G).
Similar(56)
Genetic variability in fitness may mainly be maintained by mutations, which usually have slightly deleterious effects [review in [ 10]].
The variation of genotypes among individuals, inherited from parents but still present in the DNA of each cell in the body, is the classic definition of a genetic polymorphism and we propose going back to this original definition: a polymorphism occurs in a population when the observed variation from individual to individual is not maintained by recurrent mutation.
This phenomenon is known as colour polymorphism when the main phenotypic difference is the colour of the plumage, pelage or skin, and has traditionally been defined as the existence of distinct, genetically determined colour morphs within a single interbreeding population, in such a proportion that the rarest form cannot be solely maintained by recurrent mutation [1].
It shows that the adaptive process is dominated by few co-occurring beneficial mutations of large effect, whereas a stationary wave is maintained by many mutations of smaller effect.
However, as murein hypertrophy is likely also to disrupt cell division, viability would probably need to be simultaneously maintained by independent mutations in the septation machinery.
In principle, multiallelic CNV is subject to the same population genetic forces as other variation, being generated by mutation, maintained by balancing selection or removed by directional selection or genetic drift.
In contrast, it is unlikely that an acute leukemia such as Ph+ALL is induced and maintained by only one mutation.
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