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The assumption that population frequency of each pathogenic allele is preserved by mutation-selection balance may be too strong.
Therefore, we assume here that the total of the population frequencies of the pathogenic alleles at each risk locus is preserved by mutation-selection balance.
The strontium sensitivity of TMEM16A-CaCCs was drastically reduced by charge-reversing arginine mutations (EC50: >10 mM at both sites) and was partially preserved by charge-preserving aspartate or glutamate mutations (EC50: 70 ± 20 μM and 90 ± 10 μM, respectively), confirming the importance of side chain charge in divalent cation coordination at these two sites.
Duplicate genes may be preserved by a neutral mechanism in which each paralog accumulates loss-of-function mutations (degeneration) that are complemented by the other copy.
However, in the case of deleterious mutations, a compensatory mutation may occur that renders the two mutations neutral or beneficial as a pair and causes them to be preserved by selection.
Our results clearly consolidate a scenario in which mutation and drift govern synonymous changes in mitochondrial protein coding genes, while gene function is strongly preserved by purifying selection.
Fort Bourke is preserved by the Royal Australian Historical Society.
However, endochrony is not preserved by composition.
The head was preserved by smoking.
Fruit bodies may be preserved by drying.
Have X-rays been preserved by you?
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