Sentence examples for maintain high expression from inspiring English sources

Because Lfng or Mfng expression weakens Notch1-Jag1 cinteractionsons, a Lfng-expressing cell could maintain high expression levels of cis-Jag1 without compromising its ability to receive signals from trans Dll1 ligands through Notch1.

We demonstrate that these oligospecific antibody formats maintain high expression level, thermostability, and protease resistance.

The expression level of these 6 genes with native promoters may vary depending on growth stage in wild type, but is supposed to maintain high expression levels in all conditions with the overexpression promoter provided (pDL1 Vector).

Because siRNA-mediated suppression of CDK9, performed in the presence or absence of pan-caspase inhibition to exclude a possible impact of CDK9-silencing-induced apoptosis, also resulted in downregulation of cFlip and Mcl-1, we can conclude that CDK9 is required to maintain high expression of these anti-apoptotic proteins in cancer cells.

The results are completely in line with the previous report that constitutively activated NF- κB has shown to maintain high expression levels of Bcl-XL and FLIPL/S and confer resistance to some anticancer drugs (Wang et al, 1999; Karin, 2006).

Our experiments on cells engaged by anti-HER2 Abs showed that fast receptor internalization and degradation was followed by rapid reexpression of new HER2 molecules on the membrane surface, consistent with the capability of these cancer cells to restore and maintain high expression levels of the amplified HER2 receptor.

Even when released from the islands and reseeded, cells previously cultured in patterns maintain higher expression of MSC markers compared to cells cultured on plastic, while maintaining their ability to differentiate into adipocytes and osteoblasts.

Patients with 8q24 (CMYC) translocation expressed low levels of BCL-2 and BAX while maintaining high expression of BIM and intermediate levels of MCL-1.

Cells cultured in this manner maintained high expression levels (>99%) of pluripotency markers SSEA4 and TRA-1-60 (Figure 3C).

This gene maintained high expression levels throughout the experiment; even the lower expression values, recorded at 0 and 24 h pt were 6 times higher than the control (Figure 8A).

However, in the absence of LIF for 5 days (LIF−), the mESCs on the soft gel still maintained high expression levels of Oct3/4, Sox2, Esg1 and Tcf15, which were significantly downregulated in the mESCs on the rigid substrate (Fig. 3B, bottom).