This conserved high level of expression across mammalian species and reproductive stages suggests their important roles in mammalian ovarian function.
Genes with conserved high local centrality in the co-expression networks were most notably enriched for photosynthesis, and never for development processes, which corresponds with the observation that the photosynthesis subnetwork was dense while many developmental subnetworks were sparsely linked.
Thus, Sulfolobus genomes appear to be organized by priority, with more essential conserved genes with higher expression levels replicated early and less conserved and expressed genes replicated late.
For example, conserved miRNA - miR156 exhibited high expression during tuberization stages, with highest level at PT0 (Additional file 1).
A few conserved miRNA families such as miR156, miR166, and miR168 showed high expression levels (more than 10,000 RPM) in both the libraries.
For example, miR2188 and miR3522b exhibit high expression levels in all four libraries and are conserved across many species.
To do this, we split the expression context conservation scores of all 1 2 orthologous groups into two data sets: one containing the highest (most conserved) expression context conservation scores, the other containing the lower (less conserved) scores.
It is suggested that conserved miRNAs usually have higher expression and that lineage specific ones are expressed at lower levels or in specific tissues, developmental stages or conditions [ 29, 75].
Other pairs of high expression were BCAL0269-0270 (oxidoreductand and ferric reductase; Table 4) and BCAM1676-1677 (nitreductasehite reductand and conserved hypothetical protein; Table 4).
CG4585 encodes a poorly conserved putative phosphotransferase with highest expression in the larval midgut and adult ovary (Chintapalli et al. 2007).
