Sentence examples for sustained high expression from inspiring English sources
Many studies have demonstrated that sustained high expression of SAA may contribute to atherogenesis [4], [5], and that an elevated concentration of SAA is associated with an increased risk of CVD [6].
Thus a sustained high expression of ID3 might trigger abnormal immunity in SLE patients, facilitating the production of autoantibodies.
Several metalloproteinases and cathepsins associated with human arthritis showed sustained, high expression during the entire disease course (Table 1, and Table S10 in Additional file 10).
Cessation of oscillations of both proneural and Hes proteins coincides with fate choice decisions, and results in sustained high expression of proneural proteins to drive differentiation, with reciprocal sustained low expression of Hes inhibitors.
The induction of early transcriptional factors, C/EBPβ and C/EBPδ, in TRIM23-depleted cells with ectopic expression of PPARγ2 was largely rescued to levels comparable to those in control 3T3-L1 cells during adipocyte differentiation, except for sustained high expression level of C/EBPβ after day 4.
Thus, these results strongly suggest that the optimized piggyBac system is a valuable tool for making stable cell lines with sustained, high transgene expression.
Sustained, high level transgene expression in mammalian cells is desired in many cases for studying gene functions.
In skeletal muscles of the treated limb at 3-months after vector administration we report widespread vector biodistribution, and sustained high level MD expression (up to 95% of fibres).
Here, we used lentivirus as gene delivery tools for random insertion of the transgene and our data confirm that the ACTB promoter has the potential to generate sustained high level transgene expression in long term culture of undifferentiated hESCs.
The fourth category of genes included those with a sustained high level of expression before and after drug treatment.
Furthermore, genes in cluster III had sustained high levels of expression under the severe drought but no obvious induction under moderate drought, suggesting that their function might not be active under moderate drought.
