TODAY Study Group et al. A clinical trial to maintain glycemic control in youth with type 2 diabetes.
Some patients with type 2 diabetes mellitus (T2DM) receiving monotherapy with a sulfonylurea (SU) are unable to meet recommended glycemic targets over the long term and require additional pharmacologic agents to maintain glycemic control.
Over the trial's 12-month duration, eight newly diagnosed diabetic subjects who got a placebo treatment required steadily increasing insulin doses to maintain glycemic control.
It may be that Myd88−/− animals maintain adequate functional reserve to maintain glycemic control under normal circumstances and their reduced islet mass only become functionally relevant upon injury.
However, following nephrectomy, M1, M3, M9 and M12 were able to maintain glycemic control (180±47, 136±30, 166±20, and 152±37 mg/dl, respectively), indicative of functional recovery of the native beta-cells.
Those with insurance coverage are more likely to maintain glycemic control than those without (13, 14).
11 Therefore, hypoglycemia limits the ability to achieve and maintain glycemic control.
Three patients receiving exenatide required rescue therapy with SC insulin to maintain glycemic control.
Diabetes is a progressive disease that typically requires ongoing therapeutic adjustments to maintain glycemic control (16).
1 Once metformin fails to maintain glycemic control another antidiabetic drug should be added.
Treatment with rosiglitazone/metformin was discontinued, and the patient was started on metformin and glipizide to maintain glycemic control.
