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In the intention to treat analysis, 62% of subjects switched to exenatide maintained glycemic control (HbA1c increase <0.5%) as compared to 81% of the insulin treated group.
Long-term (3 years) exenatide treatment is associated with maintained glycemic control, progressive weight loss, and improved β-cell function (48).
In this work, we present a population level estimate of HbA1c testing frequencies and treatment consequences among commercially insured adults and Medicare Advantage beneficiaries with type 2 diabetes across the USA who have achieved and maintained glycemic control without use of insulin.
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TODAY Study Group et al. A clinical trial to maintain glycemic control in youth with type 2 diabetes.
Some patients with type 2 diabetes mellitus (T2DM) receiving monotherapy with a sulfonylurea (SU) are unable to meet recommended glycemic targets over the long term and require additional pharmacologic agents to maintain glycemic control.
Long-acting insulin analogues (eg, insulin glargine and insulin detemir) are an alternative to neutral protamine Hagedorn (NPH) insulin for maintaining glycemic control in patients with diabetes.
Over the trial's 12-month duration, eight newly diagnosed diabetic subjects who got a placebo treatment required steadily increasing insulin doses to maintain glycemic control.
It may be that Myd88−/− animals maintain adequate functional reserve to maintain glycemic control under normal circumstances and their reduced islet mass only become functionally relevant upon injury.
However, following nephrectomy, M1, M3, M9 and M12 were able to maintain glycemic control (180±47, 136±30, 166±20, and 152±37 mg/dl, respectively), indicative of functional recovery of the native beta-cells.
Those with insurance coverage are more likely to maintain glycemic control than those without (13, 14).
Insulin treatment is neither durable in maintaining glycemic control nor is unique in preserving β-cells.
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