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These studies provide real-life data and, although they lack a control arm, suggest the possibility of pump therapy having durability in sustaining glycemic control.
It was reported that despite differential effects on measures of adiposity among the treatment groups, group differences generally were small and unrelated to treatment effects in sustaining glycemic control (7).
Despite differential effects on measures of adiposity (with M+R resulting in the most and M+L in the least fat accumulation), group differences generally were small and unrelated to treatment effects in sustaining glycemic control.
The addition of vildagliptin to a stable dose of metformin monotherapy has been shown to be effective in sustaining glycemic control for at least 1 year, and in improving β-cell function and reducing insulin resistance and inflammatory markers [ 43- 47].
Data presented herein indicate that the treatment group differences reported (2) in the primary outcome analysis (superiority of M+R in sustaining glycemic control compared with M, with M+L intermediate) are not explained by concordant differences in BMI or whole-body adiposity.
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Indeed, a single s.c. injection of ELP-FGF21 affords up to five days of sustained glycemic control in ob/ob mice.
Henry, R. R. et al. Continuous subcutaneous delivery of exenatide via ITCA 650 leads to sustained glycemic control and weight loss for 48 weeks in metformin-treated subjects with type 2 diabetes.
This beneficial effect was not enough to sustain glycemic control.
14 Thiazolidinediones as monotherapy have also been shown to provide more sustained glycemic control compared with sulfonylureas.
Thus, patients who switched to exenatide ER from sitagliptin or pioglitazone had improved or sustained glycemic control with weight loss.
Effective and sustained glycemic control in type 2 diabetes is unlikely to depend only on rational treatment.
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