Sentence examples for maintain downstream from inspiring English sources

p16 is cyclin-dependent kinase inhibitor, which can maintain downstream Rb protein in a hypophosphorylated and active state.

Indeed, multiple RTKs may be coactivated in tumors and redundant inputs drive and maintain downstream signaling [ 18, 19], although other possibilities should not be ruled out.

Thus, even though 8 mg/kg NVP-AUY922 appeared to cause a slight reduction in HSP90-p23 complexes, the remaining complexes are likely sufficient to maintain downstream signaling as evidenced by AKT phosphorylation.

The exact protein expression levels of RAGE necessary to maintain downstream signal transduction is not known, but the observed reduction in RAGE expression was more pronounced than in other studies demonstrating RAGE-dependent effects [ 34], suggesting that the observed S100A4-mediated activatiof of NF-κB is RAGE-independent.

To test whether positioning was maintained downstream from transcribed regions, we used the terminal nucleosome (TN, the closest upstream from the TTS) as a reference for the alignment.

To assess whether diabetes-induced blunting of Akt activation was maintained downstream, several other insulin-responsive proteins were investigated via Western blot analysis, including mTor (protein synthesis), p70S6K (protein synthesis), AS160 (glucose uptake), and GSK3β (glycogen synthesis).

These studies suggest that c-Met and EGFR have a compensatory relationship, whereby inhibition of one receptor tyrosine kinase (RTK) may result in the activation of the other, thus maintaining downstream signalling (Lai et al, 2009).

The objective of this system is to maintain the downstream end water level of each pool at constant target value under external uncontrolled perturbation.

We estimate that this accumulated during ∼5 3 Ma when uplift rates were low, such that aggradation was necessary to maintain a downstream channel gradient in response to the coastal retreat.

This will maintain the downstream CAR target genes in an active mode and ensures a rapid and efficient turnover of the xenobiotic metabolic pathway.

Retinal arterioles also contribute to increased vascular resistance and maintain the downstream pressure balance, causing dilation of small caliber arteries.