Sentence examples for sustained downstream from inspiring English sources
These observations suggest that phosphorylation of FRS2 and consequent recruitment of GRB-2 via FRS2 is essential for a sustained downstream phosphorylation of p42/44 MAPK, whereas recruitment of GRB2 directly to the FGFR results only in a transient phosphorylation of p42/44 MAPK.
VEGF-A binding to VEGFR2 triggers receptor dimerisation, linked to the activation of its tyrosine kinase domain, which triggers sustained downstream signal transduction integrated with receptor ubiquitination, trafficking and proteolysis (Bruns et al., 2009; Horowitz and Seerapu, 2012; Koch and Claesson-Welsh, 2012; Nakayama and Berger, 2013).
For instance, an instantaneous ligand addition could lead to sustained downstream responses due to the non-linearity of the downstream processes.
Recent biochemical approaches based on chemical crosslinking support the idea that CEACAM1 oligomerizes laterally via the transmembrane domain to sustain downstream function [ 50].
However, the role of CNG channels and Ca2+ stores in generating transient and sustained signals downstream from the cone OS is unclear.
The Native American Havasupai group that lives at the bottom of the canyon just beyond the boundary of the national park, next to waterfalls tumbling into famed turquoise pools, complained that the vast new development would suck up scarce water resources that sustain their downstream community.
A comparison of the variations of differential diffusion, turbulent mixing, heat release rate and probability of encountering explosive zones demonstrates that differential diffusion predominantly plays an important role for mixture preparation and initiation of chemical reactions, closely followed by intense chemical reactions sustained by sufficient downstream turbulent mixing.
These all suggested that the endocytosis of MIF and downstream sustained ERK activation are both mediated by receptor, CD74.
However, what is clear is that when SMDF is expressed in the same cell as its receptor, it leads to constitutive activation of the ErbB-2 receptor and sustained activation of downstream signalling pathways.
Aberrant activation of EGFR plays an important role in breast carcinogenesis via the sustained initiation of downstream cascades that promote cell survival and proliferation.
CYT-1 ERBB4-induced tumors may develop either directly by sustained and enhanced downstream ERBB4 signaling in a FVB genetic background, or from ERBB4 signaling acting in concert with secondary genetic or epigenetic alterations acquired over a 1-year period.
