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It does so mainly by interacting with hemochromatosis (HFE) protein.
Phenothiazine tranquilizers as well as α2-agonists exert their hemodynamic effects mainly by interacting with α-adrenergic-receptors.
In fact, the role of antiapoptotic factors like Bcl-2, Bcl-XL, and Bcl-w is to suppress autophagy, mainly by interacting with Beclin 1 [ 12].
As shown in panels C and D of Figure 1, the thumb, palm, and finger subdomains hold DNA mainly by interacting with the DNA backbone.
It functions both as a cell attachment and chemotactic protein, mainly by interacting with integrins through an RGD domain, and also by interacting with CD44 (Denhardt et al, 2001).
The anti-apoptotic members of this family have been reported to suppress autophagy, mainly by interacting with and therefore inhibiting Beclin-1, whereas the pro-apoptotic members of this family and other BH3-only proteins, including Bad, Bik, BNI-P3L, Noxa, Puma, and BimEL, promote autophagy by freeing Beclin-1 from inhibitory interactions with anti-apoptotic Bcl-2 like Bcl-2 like
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pRb mainly acts by interacting with the E2F family of transcription factors, thereby restricting expression of genes required for cell proliferation [9].
VEGF mainly operates by interacting with three receptors: VEGFR-1, VEGFR-2, and NRP-1.
It is presumed that cadmium mainly adsorbed on bacterium by interacting with nitrogen atoms of amide groups.
These data indicated that sHLA-G inhibited T cell chemokine receptor expression by interacting mainly with ILT2/CD85j, although other sHLA-G receptor(s) are likely involved.
ICAM-1 also participates in the inflammatory response to lipopolysaccharide-induced lung injury by interacting mainly with neutrophils [ 19].
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