Sentence examples for mainly by binding from inspiring English sources

In addition, we also found that PGA1 binds to and activates H-, N- and K-Ras [34] mainly by binding to the cysteine 118 located in the GTP-binding motif, thus differing in the site of interaction of 15d-PGJ2 witH-Rasas.

RA exerts its biological action mainly by binding and activating specialized transcription factors, the RA-receptors (RARs) [3].

TGF-β1 regulates cellular processes mainly by binding to three high-affinity cell-surface receptors known as types I, II, and III (TbRI, II, III).

The action of amphiregulin is mediated mainly by binding to the epidermal growth factor receptor (EGFR) also known as ErbB1 or HER1.

It also regulates postnatal bone accretion and maintenance of bone mass mainly by binding to Lrp5/6 in a process that involves the transmembrane proteins Kremen 1 or Kremen 2 [38], [38], although at least some of the Wnt-inhibitory effects of Dkk1 mediated by Lrp5/6 seem to be independent of Kremen [39].

V acts in heart mainly by binding of GLP-1 in GLP-1R (22, 31).

Tetracycline inhibits binding of RNA to ribosomes mainly by influencing binding to the A-site although some reports implicate binding of Ac-Phe-tRNA to the P-site 57, 58.

It was found that the separation was pH-dependent and mainly determined by binding strength with the possibility of involvement of other interaction, providing alternative strategy for the separation of cis-diol compounds.

HSP70 transcription in response to heat stress is mainly mediated by binding of heat shock transcription factor 1 (HSF1) to heat shock elements (HSE) in the promoter region of HSP70 gene.

Reboxetine, the first selective norepinephrine (noradrenaline) reuptake inhibitor used in the treatment of depression, 1 mainly acts by binding to the norepinephrine transporter and blocking reuptake of extracellular norepinephrine.

miRNAs mainly act by binding to the 3′-untranslated region of their mRNA targets (Ambros et al. 2003; Bartel 2004; Ghildiyal and Zamore 2009), although that is not the only function attributable to these molecules.