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The analysis of the contribution of the single and combined domains suggest that the UBA domain negatively modulated the USP25 function mainly by interaction with the UIM1 domain.
Since WISP-1 is a secreted protein and functions mainly by interaction with ECM, the difference in findings might reflect the difference in ECM in vivo and in vitro.
These peptides would have different functions in the lung as they contract smooth muscle cells mainly by interaction of NKA with NK-2R, while an increase in vascular permeability and pro-inflammatory effects are mediated by SP on the NK-1R [16].
Antifungals can lead to inhibition of fungal growth, mainly by interaction with the fungal cell membrane through inhibition of sterol synthesis or inhibition of the synthesis of cell walls (Kathiravan 2012).
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ΔGBACh is set mainly by interactions of ACh with just three binding site aromatic groups.
Soil biogeochemical functions in flood-plains are controlled mainly by interactions between river flooding dynamics and vegetation change.
In this study, we investigate the origin of the seepage fluids on the Oomine Ridge by examining concentrations of B. The level of B in seepage fluids is controlled mainly by interactions of sediment or rock with water, which depends on the temperature of the reaction (You and Gieskes [2001]).
Interestingly, binding of ctPan2 to ctPan3 is mediated mainly by interactions between main chain atoms, not side chains.
Mouse breast tissue undergoes continuous changes throughout the lifespan of reproductively active females, mediated mainly by interactions between the mammary epithelium and the surrounding mesenchyme.
Calcium homeostasis in vivo is thought to be governed mainly by interactions between 1,25- OH 2D3 and parathyroid hormone (PTH) with PTH being the major factor responsible for maintaining osteoclastic activity.
The calculated results indicated that c RGDfK) interacted with αvβ3 mainly by electrostatic interaction, stabilization interaction, and hydrophobic interaction.
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