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Both drugs reduce the main defect in the pathology which corresponds to muscle weakness and degeneration.
These findings suggest that the main defect in Oa1-deficient melanocytes consists in a lower frequency (rather than velocity) of MT-based movements.
Although the underlying mechanism remains unclear, available evidence suggests that the main defect in the pathogenesis of GDM is relatively diminished insulin secretion coupled with pregnancy-induced insulin resistance (17).
Accumulating evidence suggests that the main defect in the pathogenesis of GDM is relatively diminished insulin secretion coupled with pregnancy-induced insulin resistance, although the underlying molecular mechanism remains unclear (3).
To test whether a reduction in the number of POMC neurons may be the main defect in BBS mice, we compared the number of these neurons in the hypothalamic arcuate nucleus between wild-type and BBS mice.
With the help of light microscopic in situ hybridization, the mRNA for COMP was detected in the cytoplasm of chondrocytes of the superficial and middle zones of healthy cartilage tissue (data not shown) and also in chondrocytes mainly found in clusters in the area adjacent to the main defect in OA cartilage.
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Threading dislocations and stacking faults are the main defects in the films.
Longitudinal bow is one of the main defects in the cold roll forming products which is affected by the bending angle increment.
Large grains emerge above the near-interface region and grain boundaries become the main defects in the upper part of the BP film.
Third, perhaps the main defects in the Hippo signalling core can be attributed to altered post-translational modifications (PTMs) at the protein level, in which case genomic data cannot be used.
The study also aims at finding the main defects in design and implementation and how the guidance given on radon-safe buildings in slab-on-grade houses has been followed.
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Justyna Jupowicz-Kozak
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