Sentence examples for principal defect in from inspiring English sources

Our data suggest that the principal defect in the disease could be the inability to respond appropriately to oxidative stress.

In contrast, others found no effect of FAK knockout on proliferation or migration and suggested the formation and/or maintenance of vascular structures was the principal defect in FAK-knockout endothelial cells (Ilic et al., 2003; Braren et al., 2006).

The fact that exogenous αSNAP can rescue acrosomal exocytosis in these cells is a strong evidence that the principal defect is a malfunction in the endogenous protein.

The principal defect of this account is that it makes the belief component of intention epiphenomenal.

Mutations in the hABCD1/ALDP gene are the principal inherited defect in adrenoleukodystrophy, a clinically heterogeneous X-linked recessive disorder characterised by adrenal insufficiency and neuronal demyelination [ 57].

Our model has also allowed us to identify altered calcium handling as one of the principal defects contributing to ventricular dysfunction in this model, and a potential target for therapeutic manipulation.

The faulty Rb and p53 proteins are a major defect in many solid tumors, unlike leukemias, where a hyperactive signaling protein seems to be the cancer's principal driver.

That's a defect in some respects.

"It is a defect in my nature".

"That is a defect in the design".

It's difficult to find a defect in Mourinho.