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Since the 19F spin was located neighboring to the active hydroxyl group, phosphorylation of the tyrosine immediately resulted in 19F chemical shift differences (i.e. −134.54 ppm for dephosporylated tyrosine and −122.30 ppm for phosphorylated tyrosine) (Li et al., 2013).
Most of these approaches use the logic that closely located neighboring SNPs share the same CNV.
Paarl and Wellington are closely located neighboring towns within a peri-urban setting, and located ~35 miles from Cape Town (Western Cape, South Africa).
These workers performed jobs as choppers and transport workers and were located in neighboring municipalities to match the ex-mercury miners as closely as possible for socioeconomic factors.
However, a number of features are known to affect mutation rate: mutation type (transition versus transversion), nucleotide context (which base is at the mutation site), dinucleotide context (which bases are located at neighboring sites to the mutation), replication timing of the region and expression level of the gene.
Gaussian smoothing is necessary because current levels of sequence read coverage lead to large deviations in the number of nucleosomes located at neighboring bps, contrary to the expectation that such nucleosomes have very similar binding affinities because they occupy nearly identical sites.
Notably, motifs within a group which were derived from independent analyses of different genomic regions, libraries, or species were dominantly located at neighboring positions relative to the uncapped 5′-end.
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