Robert Kagan, of the Carnegie Endowment for International Peace, and a Kristol ally, has written critically of the Bush Administration's incomplete adherence to its own anti-tyranny doctrine.
Among women taking zidovudine, 20% reported incomplete adherence.
Incomplete adherence did not mask a benefit of early weaning.
Our data suggest that patterns of incomplete adherence, namely interruptions in treatment, may narrow this window.
Limiting sustained NNRTI treatment interruptions may improve durable virologic suppression, especially in patients with incomplete adherence.
In this study, we used <95% as a conservative cut-off point for incomplete adherence.
These methods, however, also indicated higher levels of incomplete adherence compared to clinic-based measures.
Each of the three subjects with incomplete adherence before the first pharmacokinetic sampling had 98% adherence and of the two subjects with incomplete adherence before the second pharmacokinetic sampling, one had 95% while the other had 88% adherence.
There was a significant difference in time to virologic failure between patients with complete vs. incomplete adherence.
In a separate analysis, there was no significant association between incomplete adherence and any of the patients' demographic, socioeconomic or clinical data (not shown).
For these patients with incomplete adherence, missing doses over a continuous and sustained interval may pose more risk for virologic rebound than interspersed missed doses.
