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Continuous positive airway pressure (CPAP) can mitigate these risks, although effectiveness is frequently compromised by inadequate adherence to treatment.
The frequency of inadequate adherence is usually underestimated by pre-electronic methods and thus is clinically unrecognized as a frequent cause of failed treatment or underestimated effectiveness.
Yet, most diet interventions fail to achieve meaningful weight loss in more than a few individuals, likely due to inadequate adherence to the diet.
Seventy-two (32%) self-reported inadequate adherence and 91 (40%) had virologic failure.
A difference between reported and actual monitoring in clinical practice can be a consequence of inadequate adherence to monitoring by patients (Collins et al. 2010).
In some they normalize blood pressure, but in many they don't, either because of genetic factors that don't respond to these measures, or because of inadequate adherence to healthy habits.
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Although they are proven to be clinically effective, these strategies face several challenges like inadequate vascularization, poor adherence to wound site, high cost, and inability to synthesize skin appendages.
Treatment failure, defined by the occurrence of relapses despite PQ therapy, is often ascribed to inadequate dosing, poor adherence, or reinfection (3 ).
In addition, inadequate dosing and poor adherence by patients may also increase the development of resistance (25 ).
Despite appropriate antimycobacterial treatment, the relatively low doses of isoniazid (5 mg/kg), poor adherence, or inadequate absorption of drugs because of HIV-related gastrointestinal disease may have resulted in subtherapeutic in vivo drug concentrations and thus in selection of a drug-resistant M. bovis BCG strain.
A combination of any of the following factors may be responsible for therapeutic failure: poor adherence to medicine, inadequate dosing, drug interactions, and unaffordable cost of medications.
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