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In the remaining literature, those concepts may occur in different binary combinations, singles or not at all.
If this hypothesis is true, worse results should be expected in the remaining literature but our data is not able to state this.
The remaining literature was quantitative in nature [ 13- 16].
Only four evaluations referred to clinical trials [ 15– 17, 21], while medical evidence was derived from published literature in the remaining 6 studies.
Four out of five tandem repeat families were already described in the literature; the remaining family, Oe179, was for the first time identified in this work.
In summary, this review summarizes the emerging body of evidence in this area but also acknowledges the remaining gaps in the literature.
The present paper was designed to provide a synthesis of what is known and unknown about IU, and, in doing so, proposes broad and novel directions for future research to address the remaining uncertainties in the literature.
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