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Based on the findings that entrapment of TMP in chitosan/alginate nanoparticles enhanced its activity, it was assessed whether active targeting of the nanoparticles to cell-surface receptors could further enhance this effect.

In the end, ZnO doping was demonstrated to prevent the sintering phenomenon and thus enhanced its activity over 15Cu 15Ni/Al2O3.

Site-directed mutagenesis of CYP105A1 based on its crystal structure dramatically enhanced its activity; the activity of double variants R73A/R84A and R73A/R84V was more than 100-fold higher than that of the wild type of CYP105A1.

As shown in Fig. 5D, anti- miR-205 enhanced its activity by over a 2-fold compared to scrambled oligo.

The binding of c-Myc to the miR-7 promoter enhanced its activity, while ectopic miR-7 promoted cell growth and orthotopic tumor formation in nude mice.

Over the last few years, the EC commission has considerably enhanced its activity and increased the coverage of the EC classification in terms of number of new enzymatic activities.

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Similar(52)

Trp53inp1 is an anti-proliferative protein within the p53 pathway, being transcriptionally activated by p53 and enhancing its activity upon its responsive genes, that is, p21 (Okamura et al, 2001; Tomasini et al, 2001, 2002).

Hence, we conclude that Bmi1 and Ring1A form an active heterodimeric E3 ubiquitin ligase, where Ring1A is the active component and Bmi1 greatly enhances its activity.

Moreover, bortezomib might also stabilise the active caspase-8 fragment to enhance its activity as suggested by recent reports that provided evidence for its regulation through ubiquitination and degradation.

This suggests that in tumors where Notch1 is activated Lfng insertions can cooperate to enhance its activity.

When activated by the reactive oxygen species, BiP enhances its activity as a folding molecular chaperone, keeping proteins apart.

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