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These are potential pharmacological targets to enhance stress resistance in human cells (eg, tissue conservation, cryoprotection, surgical interventions).
In addition, we obtained limited information regarding ventricular diastolic function in our cohort and hopefully, as more detailed methods (eg, tissue Doppler) are utilized, these data will become available.
However, in patients with diabetes, this regulation is disrupted, and there is an increased thrombotic tendency, due to platelet hyperreactivity, decreased fibrinolysis, and increased activation of prothrombotic coagulation factors (eg, tissue factor, factor VIII, thrombin, fibrinogen, plasminogen-activator inhibitor 1).
When plaque disruption occurs, a sufficient quantity of thrombogenic substances is exposed (eg, tissue factor), and the coronary artery lumen may become obstructed by a combination of platelet aggregates, fibrin, and red blood cells.
Similar(56)
249, 250 For instance, about 80% of the EMVs analyzed in human plasma samples obtained during a clinical study were determined to be of platelet origin, 251 and the number of nonplatelet-derived (eg, tissue-derived) EMVs were well correlated to the clinical data and disease history of the patients.
19 Clinical research will include research primarily conducted on human participants and on materials (eg, tissues, biological specimens) derived from them.
There is also a growing body of evidence that implicates many immune-related genes in normal physiological processes eg. tissue remodelling [ 33].
Not only is longevity increased, but also metabolic (eg, increased tissue sensitivity to insulin), neuroendocrine and immune (eg, increased defenses against stress, infections, cancer), and collagen responses (eg, reduction of cross-linking) are significantly enhanced (Mobbs et al 2001).
416 Biological specimens (eg, biopsy tissue; blood for DNA extraction) obtained during the conduct of clinical trials can be stored in repositories often designated as biobanks—for the current trial and future research.
18 Biological network models that represent an up-to-date summary of known biology within defined boundaries (eg, species, tissue, and disease) offer a readily human-understandable metaphor for biological relationships and are amenable to computational analysis when encoded in the appropriate format.
This, in turn, increases diversion of FA from peripheral tissues (eg, skeletal muscle and fat tissue) to the liver, thereby decreasing both FA synthesis and delivery of TG to peripheral tissues.
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