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Exact(7)
After completion of dose adaption, the individually titrated certoparin dose was to be used in subsequent dialyses.
Dose adaption was performed according to the results; only if the results were extremely high one dose was omitted.
In the amendment exploratory objectives were added to assess the course of dose adaption and the outcome of dialysis over time.
The findings from this pooled analysis of severe malaria patients receiving i.v. ARS support the dose adaption previously recommended in a separate analysis of children receiving i.m.
This failure of anti-infective prophylaxis was most probably related to the reduced levofloxacin concentration caused by renal-based dose adaption rather than because the strain had developed fluoroquinolone resistance.
Third, we did not simulate any dose regimens that would have resulted in adequate drug concentrations in our cohort of patients, and a prospective study with dose adaption during CRRT is needed in this setting.
Similar(51)
As expected, there was no cross-adaption to 1/1000 diacetyl, which is sensed by AWA, at either adapting dose.
The adaption ratio (simulated/measured mean dose) was almost perfect for individual biopsies, on average 0.99 ± 0.025.
The adaption ratio of simulated/measured mean absorbed dose was on average 0.99 ± 0.025.
Other groups also described the adaption resulting from preexposure to lower doses of ROS.
The randomised controlled trial, the Adaption de Posologie du MMF en Greffe Renale (APOMYGRE) and the fixed dose versus concentration controlled (FDCC) studies investigated the benefit of using therapeutic drug monitoring (TDM) but results were not consistent.
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