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Exact(17)
Dose adaptations were performed as described elsewhere [ 15].
No dose adaptations will be made for study purposes.
Diarrhoea peaked in cycle 2, and was reduced in the following cycles by dose adaptations.
Intradialytic heparin anticoagulation was carried out according to standard procedures and continued without dose adaptations in both arms of the study; priming of the dialyser was heparin free.
Only a few (approximately 10%) patients required dose adaptations during cross-over, primarily when treatment was switched from methadone to SROM.
In the future, this could be carried out by using first-cycle PK modelling with determination of potential dose adaptations for later cycles using Bayesian analysis.
Similar(43)
Although minimizing the likelihood of toxicity using TDM is important in critically ill patients, dose adaptation to avoid under-dosing and maximize efficacy is also valuable.
Most antimicrobials require dose adaptation during CRRT.
Neurological toxicity can be acute, requiring dose adaptation or a change of drugs.
This study showed that adding a PAD module to a NICU CPOE system improved both PAD evaluation and analgesia/sedation dose adaptation on the basis of the scores.
Treatment was initiated with a standard daily dose of 300 μg but dose adaptation was possible every 3 months from 150 to 600 μg daily.
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