diminished efficacy

USAGE SUMMARY

"diminished efficacy" is correct and usable in written English. You can use it when discussing a reduction in effectiveness or performance of something, such as a treatment or intervention. For example: "The study showed a diminished efficacy of the vaccine over time." Alternative expressions include "reduced effectiveness" and "lowered performance."

✓ Grammatically correct

Science

News & Media

Human-verified examples from authoritative sources

Exact Expressions

13 human-written examples

Although the CRAd expressing TK appeared to exhibit a slightly enhanced therapeutic efficacy both CRAds exhibited diminished efficacy when tumors contained in addition stromal cells.

Plosone

It has been theorized that incretin-based therapies have diminished efficacy with long-standing disease and fewer β-cells (15).

Diabetes Care

Although diazepam has been demonstrated not only superior to pill-placebo but also equally effective compared with alprazolam [ 56, 58], this issue could have diminished efficacy of diazepam and have diluted differences between combined therapy and psychotherapy alone.

BMC Psychiatry

She decided on her own to increase her daily dose to 15 milligrams, from the 10 milligrams prescribed by her doctor, to counteract what she perceived as diminished efficacy of the drug over time.

The New York Times

To investigate whether the diminished efficacy of ART in young poor responders compared to young normal responders is due to a quantitative or a qualitative oocyte factor.

Fertility and Sterility

Diminished efficacy of endogenous TxA2 and direct depolarisation secondary to dysfunction of the RhoA/ROK pathway may contribute to systemic hypotension in septic shock and dysregulation of regional blood flow [18,20].

Intensive Care Medicine Experimental

Human-verified similar examples from authoritative sources

Similar Expressions

47 human-written examples

Another factor that favors use of AAV5 for human gene therapy is the presence of AAV2 neutralizing antibodies in humans, which diminishes efficacy of AAV2 [42].

Plosone

Preclinical studies almost invariably show diminishing efficacy with increasing pathology at initiation of treatment.

Alzheimer's Research and Therapy

Importantly, SMN-restoring therapies demonstrate diminishing efficacy with delayed delivery consistent with the concept of a therapeutic window of opportunity for SMN-targeting therapies.

Annals of Clinical and Translational Neurology

Of note, hierarchies in signaling cascades involved in tumor development can diminish efficacy of targeted therapies if the new mutation overrides the targeted factor in the signaling cascade.

ACS Biomaterial Science and Engineering

Person with HIV often find it difficult to maintain the adherence necessary for viral suppression due to many factors, including depressive symptoms; [ 10] even infrequent non-adherence greatly diminishes efficacy [ 2, 11, 12].

BMC Medical Informatics and Decision Making

Expert writing Tips

Best practice

When discussing the effectiveness of treatments or interventions, clearly state the factors contributing to the "diminished efficacy" to provide context and inform further action.

Common error

Avoid attributing "diminished efficacy" to a single cause without sufficient evidence. Complex systems often involve multiple interacting factors.

Linguistic Context

The phrase "diminished efficacy" functions as a noun phrase, where "diminished" modifies "efficacy". It describes the state of something having reduced effectiveness. As Ludwig AI confirms, this phrase is correct and usable in written English.

Expression frequency: Uncommon

Frequent in

Science

70%

News & Media

20%

Formal & Business

10%

Less common in

Academia

0%

Encyclopedias

0%

Wiki

0%

Ludwig's WRAP-UP

In summary, "diminished efficacy" is a grammatically sound and scientifically relevant phrase used to indicate a reduction in effectiveness. Ludwig AI confirms its proper usage. While not extremely common, it appears frequently in scientific and medical contexts, as illustrated by the examples provided. When writing, it's important to provide context around the factors contributing to the reduced effectiveness and avoid oversimplifying the causes. Alternatives such as "reduced effectiveness" or "decreased potency" can be used depending on the specific nuance you want to convey.

More alternative expressions

Phrases that express similar concepts, ordered by semantic similarity:

reduced effectiveness

Focuses on the level of reduction in how effective something is.

reduced impact

Focuses on the level of reduction in consequence of something.

decreased potency

Highlights the reduction in strength or ability to produce a desired effect.

weakened effect

Emphasizes that the impact or result has become less strong.

impaired performance

Describes a decline in the ability to function as intended.

lessened impact

Indicates a smaller or weaker influence or consequence.

attenuated response

Suggests a reduction in reaction or sensitivity.

compromised effectiveness

Implies that effectiveness has been negatively affected or weakened.

eroded effectiveness

Suggests a gradual decline in how effective something is.

waning effect

Indicates that an effect is gradually decreasing or disappearing.

FAQs

How to use "diminished efficacy" in a sentence?

You can use "diminished efficacy" to describe a reduction in the effectiveness of something. For example: "The study showed a "diminished efficacy" of the vaccine over time."

What can I say instead of "diminished efficacy"?

You can use alternatives like "reduced effectiveness", "decreased potency", or "weakened effect" depending on the context.

Which is correct, "diminished efficacy" or "decreased efficacy"?

Both "diminished efficacy" and "decreased efficacy" are grammatically correct and can be used interchangeably. However, "diminished efficacy" might subtly suggest a more gradual or progressive reduction.

What factors might lead to "diminished efficacy" of a treatment?

Factors like drug resistance, disease progression, or patient non-adherence can contribute to the "diminished efficacy" of a treatment.