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After a follow-up of about three years, 11 women getting the drug had developed invasive breast cancer compared with 32 of the women receiving a placebo.
Before we had a vaccine for Haemophilis influenza type b (Hib), 20,000 infants and children each year developed invasive Hib infections, two-thirds of which resulted in meningitis, a disease that killed 600 children each year and left many others with seizures, complete hearing loss or mental retardation.
Eleven of 29 heavily colonized patients developed invasive candidiasis.
Fifty-two percent of patients met this rule, which captured 78% of those who developed invasive candidiasis.
Another important example in the USA is a spontaneous hybrid between wild radish (Raphanus raphanistrum) and cultivated (Rapahanus sativus) radish, which developed invasive hybrids.
A Swedish group prospectively followed 61433 women who were cancer free in 1987–1990 and some of them later developed invasive breast cancer [91].
The index increased significantly by 0.1 during the ICU stay (p = 0.016) and the threshold of 0.5 was reached in 36 (39.1%) of 92 nonsurgical ICU patients staying > 7 days; 6 of them developed invasive candidiasis [63].
To our surprise, while majority of the iHRAS* mice succumbed to invasive and angiogenic cutaneous melanomas in a doxycycline-dependent manner[35], a handful of the aging male mice that escaped the melanoma fate developed invasive prostate tumors (unpublished observations).
Forty-seven women developed invasive disease.
Encouragingly, only 6 (8%) patients have developed invasive disease.
Four of these cases developed invasive candidiasis prior to day 4 and were excluded.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com