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The combination of restricted variation in potentially deleterious directions and feedback between variation and stress, explains how any type of newly-forming random variation can self-organize into emergent physiological adaptations.
Interestingly, surgery did not become deleterious, whereas medical management improved.
Thus, any hybrid, regardless of cross direction, should experience the deleterious effects of separating the coevolved alleles of epistatic gene pairs.
The inverse correlation is an intrinsic outcome of natural selection which lowers the flexibility in directions that have been previously deemed deleterious.
Because the test statistic will be driven by the different clustering of the variant locations in the case and control groups, the power of the test statistic is not negatively influenced by the presence of different effect directions in the region, i.e. deleterious alleles and protective alleles.
Corticosteroids may modulate the risk of cardiovascular disease in patients with RA in two competing directions: by increasing the risk due to deleterious effects on lipids, glucose tolerance, weight gain and hypertension, 67 but conversely potentially decreasing the risk by exerting anti-inflammatory and antiproliferative effects on vascular wall.
In the presence of the oil rim, the injected gas spread and promoted a significant lateral deviation error; a single direction of penetration would have been more deleterious and would have reduced the gas injection rate and amount of gas injected to nearby wells, and it would have affected the diffusion velocity of gas in the water.
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