Sentence examples for defective background from inspiring English sources

A YopE defective background was chosen for this assay in order to avoid a repressing effect on pore formation and thereby influence of ExoS translocation efficiency [74].

In a BRCA1/2 defective background these DSBs are likely to be repaired by more error-prone repair mechanisms, causing chromosome aberrations and loss of viability [ 54].

As shown in various neoplasias, tumorigenesis can be an immune-mediated disease, melanoma being sustained by a clear immune defective background.

Strains with the pol2-Y831A mutareon are mutators in a mismatch repair defective background [ 7], suggesting that they are defective in controlling replication fidelity at a step prior to mismatch repair (MMR).

Indeed, when inter-sister HR is inhibited in such a synapsis defective background (either via brc-1 mutation, rad-51, or rec-8 RNAi), faithful meiotic DSB repair is impaired, leading to severe chromosomal fragmentation (Adamo et al. 2008; Colaiacovo et al. 2003; Smolikov et al. 2007).

The key features of these systems are: (1) use of a diverged sequence with evenly spaced single-nucleotide polymorphisms (SNPs) as a repair template for a broken molecule and (2) use of mismatch-repair defective background, which prevents repair of mismatches formed during strand-exchange reactions.

The mutation rate in dnaE915 is ∼5-fold lower than the isogenic DnaE+ control, and this effect remains in the Lex-defective background (Figure 1G, Table 1).

Aged elav>enarev individuals display extensive vacuolization in specific areas of the adult brain which correlated with a decreased response in a phototaxis assay, likely as a result of programmed cell death (Figs. 5 and 7), which was largely rescued when a general caspase inhibitor was introduced in the ena-defective background.

To examine the latter possibility, we additionally knocked out ATG1, ATG14 or ATG16 in the deconjugation-defective background.

This is in line with a previous study in yeast demonstrating that PE is a limiting factor for autophagy in a carboxypeptidase Y-defective background.

This weak activity, together with its nature to cause strong carbon catabolite repression, meant that sufficient amylase induction by d-glucose could be detected only under a CreA-defective background (Fig.  4).