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Defective protein folding as a basis of human disease.
It may therefore be a dominant negative form with normal DNA binding but defective protein interactions.
The drug PLX4032 binds to the defective protein, deactivating it.
If the blueprint is defective, a defective protein will be made.
Thomas, P. J., Qu, B. H. & Pedersen, P. L. Defective protein folding as a basis of human disease.
To replace the missing or defective protein, hemophiliacs must inject a plasma-derived, freeze-dried concentrate of the factor regularly.
The result of a defective protein, cystic fibrosis is a chronic, progressive and ultimately fatal disease that clogs the lungs and pancreas with thick, sticky mucus.
These results suggest that defective protein import into the mitochondria of the chaperone deficient mutants, which could explain the partial upregulation of cytosolic chaperones, is an unlikely scenario.
Because both proteins were expressed properly, the observed differences between the two proteins were most likely not caused by defective protein expression.
Lympho-epithelial Kazal-type-related inhibitor (LEKTI) is the defective protein of the ichthyosiform condition Netherton syndrome (NS).
Three years ago, Dr. Kunkel and his colleagues showed that cells from a donor mouse's marrow would incorporate into the recipient mouse's muscles and contribute the correct form of dystrophin, the defective protein in muscular dystrophy.
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