Sentence examples for by methodological issues and from inspiring English sources

Evidence is limited by methodological issues and is based primarily on case control designs.

However, their value can be compromised by methodological issues and the presence of multiple divergent copies within a single individual.

The authors cautioned that the quality of evidence pertaining to thoracic, abdominal, and extremity injuries may be limited by methodological issues and lack of data to a greater extent than findings that pertained to head, neck, and facial injuries [ 7].

There are yet few studies on electronic self-monitoring in bipolar disorder, and the evidence of electronic self-monitoring has been sparingly investigated and is limited by methodological issues and by a lack of RCTs [ 51].

The Swedish general population data were taken from two studies with different age ranges so as to better match the total age range in the Swedish CF sample, and our comparisons may therefore have been affected by methodological issues and potential changes in anxiety and depression prevalence over time.

Previous studies and estimates have been hampered by methodological issues including small sample sizes and lack of objective measures.

When evaluating gender differences in mental disorders and suicidality, specifically between European countries, studies are sparse and frequently hindered by methodological issues, such as the limited items evaluated and inconsistent sampling designs.

Inflammatory system dysregulation may be involved in the pathophysiology of bipolar disorder with peripheral cytokine levels varying between affective states; however, the evidence is based primarily on case control studies and limited by methodological issues.

Additional risk of bias was introduced by methodological issues, such as invalid randomisation procedures and unclear blinding, leading to a grading of the current level of evidence as "low" (Luedtke et al., Clin. J. Pain, accepted) according to the GRADE system [ 52].

Associations between CCD and psychiatric disorders were influenced by methodological issues, such as validation designs (β = 16.27, 95%CI 12.75-19.79) and use of CCD multi-item checklists (β = 6.10, 95%CI 1.89-10.31).

Some of the variation between studies will be explained by methodological issues including the definitions of help-seeking and of joint pain.