Many animal studies are flawed by methodological weaknesses that compromise study validity and reproducibility.
Most trials in this area are limited by methodological weaknesses including small sample sizes and short supplementation durations, ranging from eight weeks [ 18] to four months [ 19].
Previous work in this area of dental caries disease and treatment experience and dental fear has been hampered by methodological weaknesses in the treatment of measurement error in the assessment of disease and psychological constructs.
However, the reliability of these findings is limited by methodological weaknesses of the studies.
Research in this field has been hampered by methodological weaknesses, whereof the most prominent has been sampling bias.
The reliability of this overview could be greatly influenced by any bias in the review process or by methodological weaknesses in the primary studies included.
This is partly explained by methodological weaknesses in the research we reviewed, much of which fails to account for the wide range of factors that may affect intervention implementation and outcomes in health systems.
The range of MRSA rates may reflect differences in specific national characteristics (countries with known higher MRSA rates), but may also be caused by methodological weaknesses, as seen by the quality of the included studies.
The epidemiological literature is sparse for most outcomes studied and plagued by small sample size, methodological weaknesses, and thus fails to support a conclusion of an adverse effect of phthalate exposure.
Most of these studies have methodological weaknesses and lack the use of standardized psychiatric interviews conducted by trained interviewers directly in a one-to-one relationship.
