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Conflicting findings across studies might be explained by methodological variations and by particular characteristics of the studied populations.
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Non-vertebral fractures are infrequent events; their use as a trial endpoint requires large or high-risk populations and is affected by methodological variations (Miller 2008).
These differences may be explained by methodological variations in the in vitro models used, suggesting that HAM was more affected by the experimental conditions.
Future research could advance this line of inquiry by using other methods of analyses (e.g., area under the curve; AUC), in order to better understand the effects of methodological variations and their implications for research design.
There is limited empirical data, significant methodological variation, and results cannot easily be divorced from subjective interpretation.
This difference is most likely explained by the methodological variations, regional characteristics in marketed product ranges and by differences in classifying excipients into the toxicity categories.
The discrepant results of clinical follow-up studies are best explained by substantial methodological variations, study populations of insufficient size, and short periods of clinical follow up.
However, comparisons must be made with caution due to methodological variations between studies and gaps in the literature.
Describe characteristics of rapid reviews and examine the impact of methodological variations on their reliability and validity.
The authors conclude that in gastric carcinomas the prediction of response to chemotherapy on the basis of relative tumour SUV changes is not essentially influenced by any of the methodological variations investigated (incubation period 40 or 90 min, reconstruction method FBP or OSEM and various SUV normalizations).
There are many methodological variations that can be tailored and used to prepare kodecytes (i.e. cells modified with Kode constructs), each with subtle differences in the rate and amount of FSL construct that will insert into the cell membrane.
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