Sentence examples for by a posttranslational modification from inspiring English sources

To be catalytically competent, the FAS must be activated by a posttranslational modification of the central acyl carrier domain (ACP) by an intrinsic phosphopantetheine transferase (PPT).

For example, homocysteine is formed through the transsulfuration pathway or by the demethylation of methionine via the intermediate metabolite S-adenosyl methionine, while hydroxyproline is made by a posttranslational modification of proline.

The nuclear translocation may be mediated by a posttranslational modification of SIRT2.

This work, published in 1986, was the first example of activation of a transcription factor by a posttranslational modification event.

Citrullyls are arginyl residues that have been converted from their native basic form into a neutral variant by a posttranslational modification called deimination, mediated by peptidylarginine deiminases.

This is imperative, as vasoinhibins are not a product of a separate mRNA (73, 85), but are generated by a posttranslational modification, proteolytic cleavage, of PRL.

In our approach we relaxed the strict transcriptional character of control by inserting a posttranslational modification (PTM) mechanism into the simulation.

Binding of PARPs to DNA leads to their polymerization, and by poly [ADP-ribosylation], a posttranslational modification of proteins playing a crucial role in many cell processes, they participate in DNA repair and gene transcription [ 1, 2].

Some proteins are anchored by lipid moieties added as a posttranslational modification.

Ubiquitination is a posttranslational modification by which specific lysine residues of the target protein are conjugated to polyubiquitin chains, using specific cellular ubiquitin conjugation systems.

Prenylation is a posttranslational modification required by many different kinds of proteins to ensure their proper trafficking and localization.