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GSEA was designed to detect modest but coordinated changes in the expression of groups of functionally related genes [53].

Gene set enrichment analysis approaches are designed to detect modest but coordinated changes in the expression of groups of functionally related genes [39], [40].

GSEA is designed to identify categories, families, or sets of genes where there are potentially small but coordinated changes in gene expression.

This most likely reflects the fact that small but coordinated changes in the expression of multiple genes within a metabolic or biochemical pathway can work in concert to have important effects [53].

The method is designed to detect modest but coordinated changes in the expression of sequence-based predicted target genes.

Rank-based approaches such as Gene Set Enrichment Analysis (GSEA) [ 21] are designed to detect modest but coordinated changes in the expression of sets of functionally related genes.

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Similar(51)

Changes in milking frequency during early lactation did not alter mammary cell population dynamics, but were associated with coordinated changes in mammary expression of at least 75 genes.

We conclude that IMF during early lactation does not alter mammary cell population dynamics but is associated with coordinated changes in expression of 75 genes in the mammary gland.

Adaptation to a particular environment results in part from the phenotypic consequences of hundreds of coordinated changes in gene expression, but because many levels of organization exist between an organism's transcriptome and its phenotype, it is often unclear how best to study the process of adaptation.

We review recent work on the genetic basis of interspecific differences in reproductive organ morphology and discuss possible genetic mechanisms for coordinated changes in complex syndromes.

Major advances build on this knowledge and reveal coordinated changes in gene expression occurring within single cells at sequential stages in the B cell differentiation pathway.

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