The absolute values of the calculated results are not in agreement with experimental values but the relative changes in the magnitude are accurate enough for energetic discussions.
Of note, it should be emphasized that the regional changes in Tl+-uptake rates listed in Table 1 do not reflect absolute changes in Tl+-uptake, but only relative changes in comparison to global Tl+-uptake within each vigilance state.
All these technical limitations do not allow us to measure the absolute Ktrans and Ve values but only relative changes in these kinetic parameters in one tumor between two exams.
An absolute rSO2 value did not differ between patients with and without CAS (p = 0.805), but a relative changes in rSO2 from baseline value was smaller in patients with CAS than patients without CAS (p = 0.048).
When we quantified the RNA concentrations using the mirVana PARIS kit (Ambion) and the Trizol® extraction (Invitrogen), we found the RNA amounts differed considerably, but the relative changes in the RNA levels of the different groups showed the same tendency.
Secondly, the changes in transcript abundance observed in complex tissues such as blood can be caused not only by regulation of gene transcriptional activity but also by relative changes in abundance of cell populations expressing transcripts at constant levels.
Indeed, accurately predicting the binding affinities for these two compounds, croconate and glucuronate, involved assessing not just a range of structures from steered MD simulations of GR, but also examining relative changes in the protein solvation energy of the target.
On the other hand, a number of recently reported membrane-permeable phosphorescent constructs successfully accumulate inside cells but can only reflect relative changes in oxygenation, which is due to the intrinsic uncertainty of their calibration in complex intracellular environments.
But for cross-industry deals, relative changes in valuation can turn a buyer into a seller, as About and Primedia have found.
The increased variance, thus, was not simply explained by a widening of individual distributions but was associated with independent relative changes in the average log expression levels of 3 large families of gene expression.
