Sentence examples for binding specificity in a from inspiring English sources

Allosteric effects can enhance the binding specificity in a function-oriented manner.

A key ingredient of the discriminant criteria is the presence of allosteric effects that are capable of enhancing the binding specificity in a function-oriented manner.

Here we have investigated Hox binding specificity in a Drosophila cell line that is relatively homogeneous, facilitating a rigorous comparative analysis of the binding of different Hox proteins in the same genomic background and under the same conditions.

We found that about 10.5percentt (23 out of 219) of the complexes have more minor groove-protein contacts than major groove-protein contacts suggesting that minor groove-protein contacts may play important roles in protein-DNA binding specificity in a number of protein-DNA complexes [ 32, 33].

These constructs are particularly relevant to ongoing efforts to increase the serum halflife of protein therapeutics (hGH-hIgG) 10, 42 or to achieve dual binding specificities in a single molecule (MBP-hIgG).

The lack of large, high resolution datasets generated using similar methods have limited previous studies of conservation of TF binding specificity to studies of divergence of strong core binding specificities in a limited number of cases (see e g., Bohmann et al., 1987; Struhl, 1987).

To introduce a novel binding specificity in SEA, a monoclonal antibody (mAb) specific for colon carcinoma antigen C215 was initially conjugated to SEA, and the resultant conjugate Fab-SEA could lyse antigen expressing tumour cells significantly in vitro [ 10].

Tandem ZF domains confer DNA-binding specificity in a modular manner, with sequential ZF domains binding sequential 3 nt DNA sequences in target sites.

Further, we can predict the DNA-binding specificity in a group manner, as described in Supplementary Table S3.

We can predict the DNA-binding specificity in a group manner, as described in Additional file 8. Furthermore, the amino acids were numbered as previously reported [ 5, 7, 59], and the first Leu in the Leu heptad repeats was numbered +1.

We observe a similar binding specificity in the interaction of Pellinos with a number of known Pellino substrates.