Sentence examples for binding affinity in a from inspiring English sources
In addition, 12 amino acid residues (from Pro26 to Asn37) positioned in the extracellular region of N-terminus, were identified as a homophilic domain having binding affinity in a trans-interaction19.
However, how to evaluate T cell receptor binding affinity in a high-throughput fashion and decipher the interaction between the ligand repertoire and T cell receptor repertoire are still challenging.
The structure of the enzyme-inhibitor complex presents an opportunity to improve binding affinity in a novel series of inhibitors discovered by structure-based methods.
The reagent shows a strong calcium binding affinity in a 1 1 ratio and metal selectivity in the order Ca2+>Mg2+>Sr2+≈K+≈Na+>Zn2+>Li+.
Molecular docking for the most potent compounds was performed to predict their possible binding mode within VEGFR2 active site and they showed binding affinity in a similar way to sorafenib.
In this way, the conformational changes caused by repulsion of the protonated histidines 292 at the dimer interface are relayed to the ion-binding site to modulate the Na+ binding affinity in a pH-dependent manner.
Next, we constructed several domain II loop mutant toxins and tested their binding affinity in an SPR analysis, and also performed a cell swelling assay to evaluate receptor-mediated cytotoxicity.
Comparison of binding affinity in an Aβ plate-based ELISA showed greater than 100-fold-higher affinity for fibrillar Aβ 1-42) than for monomeric Aβ 1-42) [ 208].
Other new TSPO radioligands reported include the phenoxyarylacetamides [C]DAA1106, [C]PBR28 or [F]PBR06, which have been claimed to perform better than [C]PK11195 for in vivo imaging of TSPO, based on higher binding affinity in an animal model of neuroinflammation [ 43] and high levels of specific binding in non-human primates and in human brain [ 44, 45].
Our experiments also provide a useful set of ionic binding affinities in a simplified system for testing new affinity prediction methods.
As several naturally occurring sugars in cells show binding affinities in a similar range, hexokinase may be considered as an 'emergency enzyme' in yeast cells.
