Sentence examples for binding site in a from inspiring English sources

EC154 binds to the Hsp90 ATP binding site in a manner similar to EC144 [ 52].

For clarity, we use the term "substrate phosphorylation site inhibitor" to refer to a substrate-competitive inhibitor that binds at the protein substrate binding site in a location analogous to that of the residue being phosphorylated.

Sandtner, W. et al. Ouabain binding site in a functioning Na+ /K+ ATPase.

Zocher, G. et al. A sialic Acid binding site in a human picornavirus.

We have used rational drug design based on the phenytoin binding site in a VGSC to make novel sodium channel blockers with enhanced activity and minimal acute toxicity.

We have demonstrated how inelastic neutron scattering can help us understand the interaction of H2 molecules with a binding site in a particular microporous material, Cu ZSM5, and by implication of other similar materials.

While a GTP bound to the GTase active site in G-CPV, neither ATP nor GTP was observed at the newly discovered ATP-binding site in A-CPV and G-CPV (Table 1), indicating that ATP/GTP binding to the large sub-domain of TP GTase domain is directly regulated by SAM, most likely via binding to the MT-2 domain, since the structure of S-CPV revealed only MT-2MT-2ain contained SAM.

To overcome these challenges, we have developed a minimalist approach to designing a ThT-binding site in a "peptide self-assembly mimic" (PSAM) scaffold.

We express the effective Hamiltonian of an ion-binding site in a protein as a combination of the Hamiltonian of the ion-bound site in vacuum and the restraints of the protein on the site.

- Intriguingly, resveratrol directly inhibits PI3K by targeting the class IA PI3K ATP-binding site in a competitive and reversible fashion.

CPKs are of special interest, since they represent a new class of Ca2+ sensors, having both a protein kinase domain and a calmodulin-like domain (including an EF-hand calcium-binding site) in a single polypeptide [ 9, 15].